Efficient Production of (R)-o-Chloromandelic Acid by
Recombinant Escherichia coli Cells Harboring Nitrilase from Burkholderia
cenocepacia J2315 by Dongzhi Wei and co-workers is published in Organic Process
Research and Development at DOI:10.1021/op400174a. It being OPRD and
from a group working in a Laboratory of Bioreactor Engineering, it’s going to
be an interesting read on doing a nitrilase reaction on the larger scale. We are currently working on scaling up a different
nitrilase-based reaction currently from bench scale to the “too heavy to use
normal glassware” scale so it’s good to see how others do it.
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