The abstract is very abstract: "A nitrile hydratase variant comprising substitution of at least one amino acid with another amino acid to improve two or more properties of nitrile hydratase by substitution of one or more and three or less amino acids".
The objective of the work under the patent is to produce a NHase variant with improved stability and high initial reaction rate.
It appears to be about Pseudonocardia thermophila variants, but I havent read all 77 pages of it since it tends to dwell on the very many changes to the sequence that they are protecting, both at the amino acid and nucleotide level.
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