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Tuesday 21 June 2011

Microbial production of acrylamide by nitrile hydratase

I have just obtained a copy of the "Acrylamide, Microbial Production by Nitrile Hydratase" by R-C Zheng, Y-G Zheng and Y-C Shen from the Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation and Cell Technology, published in 2010; DOI: 10.1002/9780470054581.eib004. It is new, interesting resource for how much large scale use of NHases there is going on, and includes some information I havent seen anywhere else before.
  • It gives a worldwide estimate for the biocatalytic production of acrylamide as 400,000 t/a
  • There are "more than 10 plants" in China running microbial acrylamide production using a Nocardia strain to yield a total production capacity which "has exceeded 200,000 t/a", with plans to increase this to 300,000 t/a
  • Degussa have a plant in Russia with a production capacity of 24,000 t/a using a R. rhodocrous M8 strain.
  • Mitsui Chemical have a JV acrylamide plant in Pusan, Korea.
  • SNF Floerger built a 20,000 t/a plant using the Nitto technology in 1999 (but it doesnt say where), and have plans for a further 5 of the same size.

1 comment:

Sander said...

Hi Justin,

Thanks for this article. It is indeed extremely difficult to find decent and trustworthy numbers about NHases used in acrylamide production. I was so annoyed by people just citing eachother for years and years, while it was clear that enzymatic acrylamide production was much higher than stated in academic articles.

Regards,

Sander