Self-Subunit Swapping Occurs in Another Gene Type of Cobalt Nitrile Hydratase

Liu Y, Cui W, Xia Y, Cui Y, Kobayashi M, et al. (2012) Self-Subunit Swapping Occurs in Another Gene Type of Cobalt Nitrile Hydratase. PLoS ONE 7(11): e50829. doi:10.1371/journal.pone.0050829.

Two recent articles on NHases

*Unique Biogenesis of High-Molecular Mass Multimeric Metalloenzyme Nitrile Hydratase: Intermediates and a Proposed Mechanism for Self-Subunit Swapping Maturation-

Zhou, Hashimoto, Cui, Washizawa, Mino, and Kobayashi in Biochemistry (2010)

DOI: 10.1021/bi100651v

An investigation of the subunit structure of the NHases in Rhodococcus rhodochrous J1.

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*High-yield continuous production of nicotinic acid via nitrile hydratase-amidase cascade reactions using cascade CSMRs 

Cantarella, Gallifuoco, Malandra, Martinkova, Spera, and Cantarella in Enzyme and Microbrial Technology(article in press, 2010)

DOI: 10.1016/j.enzmictec.2010.12.010

This looks at using the NHase/amidase system from Microbacterium imperiale CBS 498-74 in a bioreactor to convert 3-cyanopyridine to nicotinic acid.