Common features of cobalt and iron based NHases

With a couple of local colleagues, I have a paper in press with the International Journal of Data Mining and Bioinformatics. It is the eventual result of Joe, a mathematician asking if I had any high dimensional data sets that needed interrogating. In terms of this blog, it has a section looking at what are the main primary sequence features (using a set of one hundred NHases) which are important in distinguishing cobalt centred NHases from iron centred ones. Thanks to Marcus for all the 3D structure analysis, and spotting the hinge/loop differences first suggested as relevant to differential stability by Miyanaga in 2001

http://northumbria.academia.edu/JoeFaith/Papers/320396/Predicting_Functional_Residues_of_Protein_Sequence_Alignments_as_a_Feature_Selection_Task