The point of this blog is to follow what is going with one particular class of enzyme, nitrile hydratase. I may stray the odd time into posting about nitrilases or amidase but my research interest is more on NHases.
First up, let me give a couple of references to NHase papers where I am corresponding author:
Biotransformation of nitriles using the solvent-tolerant nitrile hydratase from Rhodopseudomonas palustris CGA009- Black, Gregson, McPake, Perry and Zhang in Tetrahedron Letters (2010) doi:10.1016/j.tetlet.2009.12.094
Probing the Enantioselectivity of a Diverse Group of Purified Cobalt-Centred Nitrile Hydratases- van Pelt, Zhang, Otten, Holt, Sorokin, Rantwijk, Black, Perry and Sheldon (accepted manuscript, 2011) DOI: 10.1039/C0OB01067G
The recombinant enzymes mentioned in these papers are available for purchase through a few companies, namely Prozomix, Almac and CLEA Technologies.
If you are a UK/EU based academic, and interested in working with our enzymes, feel free to contact me.
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