Every so often I do a quick and dirty search for the text string "nitrile hydratase" on the NCBI website under the "proteins" database tab. Just now there were 2672 proteins annotated thus, of which 985 were RefSeq. Obviously this double counts the number of enzymes (at least) because NHase is two subunit enzyme and this search doesnt distinguish between alpha and beta chains, and there are always some misannotated things... but maybe there are 400-1000 different nitrile hydratase sequences out there?
A similar text search of PDB gives 36 structures. Some are pretty similar and are plus/minus something in the active site. A rough trawl suggests that's about a dozen distinct structures.
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